noun
definition
A glycoprotein, produced in the liver, that is converted into thrombin during bleeding and subsequent clotting.
Examples of prothrombin in a Sentence
Warfarin and other coumarin derivatives Co-administration of fluvastatin with warfarin may commonly cause significant increases in prothrombin time.
Thrombin is formed from prothrombin by a prothrombin activator, itself the end of a series of reactions.
It is then carried to the liver for the synthesis of prothrombin, a key blood-clotting factor.
The factors include prothrombin, thrombin, and fibrin.
Factor VII is also called serum prothrombin conversion accelerator (SPCA) deficiency.
A deficiency of factor VII, also called serum prothrombin conversion accelerator (SPCA) deficiency, affects one in 500,000 people and is often diagnosed in newborns.
Regardless of the specific cause of DIC, the results are a malfunction of thrombin (an enzyme) and prothrombin (a glycoprotein), which activate the fibrinolytic system, releasing clotting factors in the blood.
Hypoprothrombinemia is an inherited or acquired deficiency in prothrombin, or factor II, a glycoprotein formed and stored in the liver.
Prothrombin, under the right conditions, is converted to thrombin, which activates fibrin and begins the process of coagulation.
Other tests may include prothrombin time and thromboplastic generation.
Diagnosis usually requires a number of laboratory tests that measure concentrations of platelets and fibrinogen in the blood along with measuring prothrombin time.
Factor XI deficiency is determined by measuring the specific coagulation factor as well as other coagulation tests including prothrombin time and clotting time.
Hypoprothrombinemia may be treated with concentrates of prothrombin.
Factor VII deficiency may be treated with prothrombin complex concentrates; as of 2004 factor VII is not licensed in the United States.
The activated partial thromboplastin time (APTT) is performed and will typically be prolonged while a prothrombin time (PT) will likely be normal.
Vitamin K helps the liver create a protein called prothrombin which is necessary for proper blood clotting.