noun
definition
Something produced from a single clone, especially a monoclonal antibody
adjective
definition
Genetically engineered from a single clone; used especially of a protein or antibody
Examples of monoclonal in a Sentence
Monoclonal antibodies are used to fight cancer cells in much the same way as antibodies that are produced by the body's own immune system work to fight infection.
In order to secure CAT's human monoclonal antibody drug pipeline into the future, CAT continues to develop its pool of drug targets.
One example is the 5T4 oncofoetal antigen originally defined by a monoclonal antibody raised against human trophoblast.
Elan researchers have recently shown for the first time that certain monoclonal antibodies can cross the blood-brain barrier.
Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty.
Of interest is the Dynabeads assay, an alternative method for providing CD4 cell counts using anti-CD4 monoclonal antibody-coated magnetic beads.
Clinical Outcome of Colorectal Cancer Patients treated with human monoclonal anti-idiotypic antibody.
The original rat monoclonal antibodies had been prepared from ascitic fluid, crudely fractionated with ammonium sulfate.
A solution to the immunogenicity of rodent monoclonal antibodies in human therapy would be to derive human antibodies directly from humans.
Successful treatment of active ankylosing spondylitis with the anti-tumor necrosis factor alpha monoclonal antibody infliximab.
A population of rat hybridoma cells were transfected with an expression plasmid encoding a humanized monoclonal antibody.
Proprietary CAT-354 is a fully human anti-IL13 monoclonal antibody being developed by CAT, initially as a potential treatment for severe asthma.
It is the first fully human monoclonal antibody for RA that works by targeting a key inflammatory protein, Tumor Necrosis Factor.
Monoclonal antibodies used as a treatment may for example destroy the blood cells that are causing myositis.
If clear positive results are not obtained with two monoclonal anti-D reagents it is safer to classify the patient as D negative.
Therefore, in spite of the variable proportions of each component, our results confirm that the synovial sarcoma is of monoclonal origin.
They include substances such as interferons, interleukins, growth factors, monoclonal antibodies, and vaccines.
As of 2003, more sensitive monoclonal assays had been developed for measuring hormone levels in the blood serum of women with PCOS, thus allowing earlier and more accurate diagnosis.
Immunofluorescence monoclonal antibody testing is very sensitive technique that gives a rapid diagnosis of inclusion conjunctivitis.
Obviously their selection must be compatible with the maintenance of antigen binding in the final humanized monoclonal antibody.
Negative controls utilized a mouse monoclonal antibody raised against a non-mammalian epitope.