noun
definition
An antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases.
Examples of methotrexate in a Sentence
Methotrexate affects spermatogenesis and oogenesis during the period of its administration which may result in decreased fertility.
Individuals taking Methotrexate should avoid folic acid in doses of 1mg and above unless under supervision.
Intra-arterial infusions of methotrexate have been used in the treatment of head and neck cancers.
Probenecid can severely inhibit renal excretion of methotrexate, and so is contraindicated.
There is research going on into injecting the chemotherapy drug methotrexate directly into the eyeball to treat lymphoma of the eye.
Methotrexate which interferes with purine metabolism was introduced almost 50 years ago.
Patients with a known allergic hypersensitivity to methotrexate or any of the excipients should not receive methotrexate.
It is a little similar to another drug in regular use called methotrexate.
Your child should take methotrexate on the same day each week.
Review concluding that these drugs should be reserved for patients unresponsive to at least two other disease modifying drugs, including methotrexate.
Having given methotrexate what I believed more than a fair chance, I declined.
It's nice to hear about other people using methotrexate.
This prompted us to explore the use of subcutaneous methotrexate.
After treatment with both radiation to the head and neck and intrathecal methotrexate the patient achieved complete symptom resolution.
Significant advantages for Enbrel in combination with methotrexate compared with Enbrel monotherapy and methotrexate monotherapy were also observed after 24 months.
Chronic leucoencephalopathy has also been reported in patients who received repeated doses of high-dose methotrexate with leucovorin rescue even without cranial irradiation.
Women treated with single dose methotrexate were more likely to fail medical management of ectopic pregnancy than those treated with multiple doses.
Methotrexate should be used with caution in patients taking drugs known to have antifolate potential including nitrous oxide and trimethoprim.
The use of methotrexate high-dose regimens recommended for osteosarcoma requires meticulous care due to the potential for additive or synergistic renal toxicity.
Liver toxicity Azathioprine, methotrexate, sulphasalazine and leflunomide can all regularly cause liver problems, which are reversible if the drug is discontinued.
Other types of drugs that are commonly used are the immunosuppressants (usually cyclophosphamide, methotrexate, azathioprine, or etanercept) and anticoagulants (usually heparin).
Long-term use can produce toxicity so potent drugs, such as methotrexate (MTX) and cyclosporine, are not used with children.
Methotrexate (MTX), given as a pill or as an injection, is sometimes used in extreme cases to alleviate symptoms of severe psoriasis or psoriatic arthritis.
Another drug that is used to treat JDMS is methotrexate, an immunosuppressive drug that may be taken as pills or given as an injection.
Methotrexate works by slowing down the immune system.
In some cases, the doctor may recommend another immunosuppressive drug known as cyclosporine to be taken together with methotrexate.
Methotrexate, cyclosporine, and hydroxychlorethotrexate all belong to a category of medications known as disease-modifying anti-rheumatic drugs, or DMARDs.
Other drugs that have been used to treat JA include methotrexate, sulfasalazine, penicillamine, and hydroxychloroquine.
Dextromethorphan has been reported to be effective in reversing some of the adverse effects of methotrexate, a drug that has found use in many conditions including cancer, psoriasis, and some types of arthritis.
If the ectopic pregnancy is caught early enough, a methotrexate injection may dissolve the egg, as noted by the University of Kansas Hospital.
Other times, a drug called methotrexate will be given to the mother.
Methotrexate & Misoprostol (MTX) can be used during the first seven weeks.
Methotrexate is given orally or by injection during your initial doctor visit, then Misoprostol tablets are given orally or inserted vaginally during a second office visit five to seven days later.
The doctor may use a medication called methotrexate that ends early pregnancies.