definition
Any of various simple water-soluble proteins that are rich in the basic amino acids lysine and arginine and are complexed with DNA in the nucleosomes of eukaryotic chromatin.
In the nucleus, there are globular proteins called histones, which the DNA wraps itself around.
Chromatin containing acetylated histones is open and accessible to transcription factors, and the genes are potentially active.
Within the particles, the virus DNA is associated with four cellular histones.
These different forms involve different linker histones, modulation of core histone modification and the binding of remodeling factors.
In contrast, the DNA in somatic nuclei is not fully neutralized by histones.
Histones are a class of albumins soluble in water and acids, but essentially basic in character; hence they are precipitated by alkalies.
It is remarkable that many histones are soluble in an excess of alkali.