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(informal, chiefly Canada, Northern US, New Zealand, Australia, UK, Ireland, South Africa, India, Hong Kong, Singapore, Commonwealth) Used as a tag question, to emphasise what goes before or to request that the listener express an opinion about what has been said.
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In isolation, a request for repetition or clarification of what has just been said.
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In isolation, expressing surprise or confusion
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(chiefly Canada) An interjection used to ascertain the continued attention of someone addressed by the speaker.
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Expressing apathy or lack of enthusiasm; meh.
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(Philippines) Expressing apprehension following or preceding a reasoning or excuse; uh.