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(comparable) From a higher position to a lower one; downwards.
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To or towards what is considered the bottom of something, irrespective of whether this is presently physically lower.
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(comparable) At a lower or further place or position along a set path.
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To the south (as south is at the bottom of typical maps).
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Away from the city (regardless of direction).
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At or towards any place that is visualised as 'down' by virtue of local features or local convention, or arbitrarily, irrespective of direction or elevation change.
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Forward, straight ahead.
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(rail transport) In the direction leading away from the principal terminus, away from milepost zero.
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(UK, academia, dated) Away from Oxford or Cambridge.
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To a subordinate or less prestigious position or rank.
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(sports) Towards the opponent's side (in ball-sports).
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So as to lessen quantity, level or intensity.
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So as to reduce size, weight or volume.
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From less to greater detail.
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From a remoter or higher antiquity.
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Into a state of non-operation.
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So as to secure or compress something to the floor, ground, or other (usually horizontal) surface.
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On paper (or in a durable record).
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So as to be cowed into silence.
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As a down payment.
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(crosswords, in relation to a numbered clued word) In a downwards direction; vertically.
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Used with verbs to indicate that the action of the verb was carried to some state of completion, permanence, or success rather than being of indefinite duration.
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(sentence substitute, imperative) Get down.