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A plant, Strychnos toxifera, formerly used in arrow poisons in South America due to its D-tubocurarine content
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Other South American plants with similar toxins that were also used in arrow poisons, mostly in the family Menispermaceae
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A substance containing the alkaloid D-tubocurarine, used historically as a muscle relaxant during surgery
It is, in the words of the old formula, Curare, cito, tuto, et jucunde, to cure quickly, safely, and pleasantly.
There are therefore in most prescriptions (i) a basis or chief ingredient intended to cure (curare), (2) an adjuvant to assist its action and make it cure quickly (cito), (3) a corrective to prevent or lessen any undesirable effect (tuto), and (4) a vehicle or excipient to make it suitable for administration and pleasant to the patient (jucunde).
The researches of his pupil, Claude Bernard, on curare, were equally exact and logical, and have served as the model for many subsequent investigations.
Thus curare may stop strychnine convulsions by paralysing the terminations of motor nerves, and chloroform may exercise the same effect by abolishing the irritability of the spinal cord.
In the case of curare these are masked almost at once by paralysis of the terminations of the motor nerves.
Hunters tipped their darts with a potent plant poison called curare or with poison from certain species of frogs.
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