noun
definition
The synthesis of organic compounds within a living organism, especially the synthesis of large compounds from small ones.
Examples of biosynthesis in a Sentence
We are analyzing the mechanisms and programming of antibiotic biosynthesis.
For example, one point at which heme biosynthesis may be controlled is at the first step.
However, a glitch in the biosynthesis pathway-represented by a defective enzyme-means that heme biosynthesis does not reach completion.
Although there are eight steps in heme biosynthesis, there are only seven types of porphyrias; a defect in ALA synthase activity does not have a corresponding porphyria.
Enzymes involved in heme biosynthesis display subtle, tissue-specific variations; therefore, heme biosynthesis may be impeded in the liver, but normal in the immature red blood cells, or vice versa.
Porphyrias affecting heme biosynthesis in the liver were referred to as hepatic porphyrias.
Porphyrias that affect heme biosynthesis in immature red blood cells were referred to as erythropoietic porphyries.
Hepatoerythopoietic porphyria (HEP) affects heme biosynthesis in both the liver and the bone marrow.
The underlying cause of all porphyrias is a defective enzyme important to the heme biosynthesis pathway.
Owing to deficient ferrochelatase, the last step in the heme biosynthesis pathway-the insertion of an iron atom into a porphyrin molecule-cannot be completed.
Making this determination yields a strong indicator of which enzyme in the heme biosynthesis pathway is defective; which, in turn, allows a diagnosis of the particular type of porphyria.
Other biochemical tests rely on the fact that heme precursors become less soluble in water (able to be dissolved in water) as they progress further through the heme biosynthesis pathway.
It exerts its effects directly in inflamed tissues underlying the site of application, mainly by inhibiting prostaglandin biosynthesis.
However this is not the case for the chloroplast complex which plays a distinct role in supplying acetyl CoA for fatty acid biosynthesis.
Returning to the more orthodox version of the cannabinoid biosynthesis, the role of ultraviolet light should be reemphasized.
Inhibition of glycolipid biosynthesis does not reverse multidrug resistance in cancer.
Further analysis of the microarray data has suggested roles for these regulatory elements other than in the control of flagellar biosynthesis.
One main focus of our research is on enzymes involved in tetrapyrrole biosynthesis.
Although the pathway for lignin biosynthesis was outlined many years ago, important basic features are still poorly understood.
An area of research for several years has been proteins and enzymes involved in lipid biosynthesis.
Indeed, luteolin also efficiently blocked the insulin effect on cholesterol biosynthesis.
These results are in conformity with the lack of genetic regulation of amino acid biosynthesis in Streptomyces.
Remarkably neither route for SA biosynthesis is completely elucidated.
Many of the novel predicted genes are associated with surface polysaccharide, flagellar biosynthesis and modification in addition to hypothetical genes.
This enzyme is believed to be involved in the biosynthesis of isoleucine in methanogens and possibly other species lacking threonine dehydratase.
It is a xanthine oxidase inhibitor and accordingly inhibits the biosynthesis of uric acid.
Biosynthesis of heme is a multistep process that begins with simple molecules and ends with a large, complex heme molecule.
Owing to a defect in one of the enzymes of the heme biosynthesis pathway, protoporphyrins or porphyrins (heme precursors) are prevented from proceeding further along the pathway.
Specific symptoms depend on the point at which heme biosynthesis is blocked and which precursors accumulate.
Heme is produced in several tissues in the body, but its primary biosynthesis sites are the liver and the bone marrow.
Much of the heme biosynthesis pathway is dedicated to constructing the porphyrin molecule.
An iron atom is placed at its center point in the last step of heme biosynthesis.
The control of heme biosynthesis is complex.
As a result, larger quantities of heme precursors are fed into the biosynthesis pathway to step up heme production.
Hematin seems to work by signaling the pathway of heme biosynthesis to slow production of precursors.
It causes heme biosynthesis to decrease, preventing the further accumulation of heme precursors.
Additional tests include plasmalogen biosynthesis potential.