noun
definition
Any of a group of disorders in which the fibrous protein amyloid is deposited in an organ of the body.
Examples of amyloidosis in a Sentence
Amyloidosis is a potentially serious condition in which proteins called amyloids are mistakenly produced and deposited in organs and tissues throughout the body.
Adapted from Husby 1994 amyloidosis seen in rheumatological practice is usually the type known as ' reactive amyloidosis ' .
Mr Brandreth has Al amyloidosis complicated by autonomic neuropathy, an extremely serious presentation of this rare disorder.
The diagnosis of amyloidosis is histological, ie proof of AA amyloid deposition in biopsy material.
Left untreated, amyloidosis often leads to kidney failure, which is the major long-term health risk in FMF.
The mainstay of treatment for FMF is an oral medication called colchicine, which is highly effective for the fever and pain that accompany the disorder, as well as for amyloidosis and the kidney disease that can result from it.
The presence and deposition of excess SAA is known as amyloidosis.
Amyloidosis may affect the gastrointestinal tract, liver, spleen, heart, and (in males) testes, but its effects on the kidneys are of greatest concern.
The frequency of amyloidosis varies among the different ethnic groups, and its overall incidence is difficult to determine because of the use of colchicine to avert the problem.
Left untreated, however, those individuals who do develop amyloidosis of the kidneys may require a kidney transplant or may even die of renal failure.
The frequency and severity of a person's attacks of fever and serositis seem to have no relation to the risk of developing amyloidosis.
In fact, a few people with FMF have been described who have had amyloidosis but apparently no other FMF-related symptoms.
Unexplained recurrent fevers, polyserositis, skin rash, and/or joint pain; abnormal blood studies (see below); and kidney or other disease associated with amyloidosis.
Colchicine is also effective in preventing, delaying, or reversing kidney disease associated with amyloidosis.
Most will have very few, if any, attacks of fever and polyserositis and will likely not develop serious complications of amyloidosis.
Primary amyloidosis usually occurs as a complication of multiple myeloma.
Secondary amyloidosis occurs in patients suffering from chronic infections or inflammatory diseases such as tuberculosis, rheumatoid arthritis, and Crohn's disease.
Other Complications About 10 per cent of patients with myeloma develop primary amyloidosis.
Another cause of kidney damage is a condition called amyloidosis which occurs in 10-20% of cases.
Neurological storage disease has been reported in this breed and renal amyloidosis, a form of kidney disease, has also been seen.